Effects of Inadvertent Perioperative Hypothermia on Metabolic and Inflammatory Mediators [Turk J Anaesthesiol Reanim]
Turk J Anaesthesiol Reanim. Ahead of Print: TARD-94715

Effects of Inadvertent Perioperative Hypothermia on Metabolic and Inflammatory Mediators

Halide Aydın1, Tuncer Simsek2, Yavuz Demiraran3
1Department of Anesthesiology and Reanimation, Van Education and Research Hospital, Van, Turkey
2Department of Anesthesiology and Reanimation, Canakkale Onsekiz Mart University, School of Medicine, Canakkale, Turkey
3Deparment of Anesthesiology and Reanimation, Medipol University, School of Medicine, İstanbul, Turkey

Objective: The study is aimed to investigate the effects of perioperative undesirable hypothermia on inflammatory (IL-8, IL-10, IL-18, IL-23 and PTX-3) and metabolic responses (cortisol and insulin) and the recovery time.
Methods: A total of 60 patients between the ages of 18 and 65, who were in the Lomber stabilization operation, were included in the study. In this prospective, randomized controlled study, two groups were constituted as with warmed (grup N) and not warmed (grup K) patients before and during the operation. Diuresis, bleeding quantities, body temperature, side effects, were recorded with IL-8, IL-10, IL-18, IL-23, PTX-3, cortisol and insulin levels.
Results: Perioperative diuresis was significantly higher in group K. Aldrate score was significantly higher in group N with less shivering and vomiting in postoperative period. IL-10, PTX-3 and cortisol levels were found to be significantly elevated in group K in the first postoperative hour. PTX-3 and cortisol were found to be significantly elevated in group K after 24 hours of the operation. Insulin was significantly elevated in group N. In 72nd hour IL-8 in group N and cortisol level in group K was significantly higher.
Conclusion: Positive effects of heating the patients in periopetive period on hemorrhage, diuresis, complications and recovery time was observed in our study. Also maintenance of normothermia appeared to modulate the biomarkers that indicate the inflammatory and metabolic responses.

Keywords: hypothermia, inflammation mediators, cortisol, insulin




Corresponding Author: Tuncer Simsek, Türkiye


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