The Effect of Anaesthetic Techniques on Maternal and Cord Blood Brain-Derived Neurotrophic Factor Levels [Turk J Anaesthesiol Reanim]
Turk J Anaesthesiol Reanim. 2018; 46(2): 139-146 | DOI: 10.5152/TJAR.2018.90187  

The Effect of Anaesthetic Techniques on Maternal and Cord Blood Brain-Derived Neurotrophic Factor Levels

Mehmet Aksoy1, Ayse Nur Aksoy2, Ali Ahıskalıoglu1, Ilker Ince1, Esra Laloglu3, Aysenur Dostbil1, Mine Gursac Celık1
1Department Of Anesthesiology And Reanimation, Faculty Of Medicine, Ataturk University, Erzurum, Turkey
2Department Of Obstetrics And Gynecology, Nenehatun Hospital, Erzurum, Turkey
3Department Of Biochemistry, Faculty Of Medicine, Ataturk University, Erzurum, Turkey

Objective: Brain-derived neurotrophic factor (BDNF), a member of neurotrophins, plays a critical role in neuronal tissue. In this study, the effects of spinal or general anaesthesia on cord and maternal peripheral blood BDNF and malondialdehyde (MDA) levels were investigated in patients undergoing elective caesarean section.
Methods: Eighty patients with term pregnancy were included. General anaesthesia was induced with intravenous (IV) propofol 2 mg kg-1 in the general anaesthesia group (n=36). In the spinal anaesthesia group (n=35), hyperbaric bupivacaine 0.5%, 9 mg (1.8 mL) was injected intrathecally. Maternal blood samples were taken immediately after positioning the patient on the operating table (T1), before clamping the umbilical cord (T2) and 24 hours after the first sample was obtained (T3). Cord blood samples were drawn from the umbilical artery (T4).
Results: Maternal BDNF levels (pg mL-1) measured at T2 time point were higher in the general anaesthesia group compared to the spinal anaesthesia group (p<0.001). Cord blood BDNF levels were higher in the general anaesthesia group compared to the spinal anaesthesia group (p<0.001). In both groups, cord blood BDNF levels were significantly lower compared to the maternal blood samples collected at any time point (p<0.001, for all). There was a negative association between both maternal and cord blood BDNF levels with maternal MDA and cord blood MDA levels, respectively (r=−0.379, p<0.001; r=−0.375, p=0.001, respectively).
Conclusion: The anaesthetic technique may have an influence on maternal peripheral and cord blood BDNF levels.

Keywords: Anaesthetic technique, brain-derived neurotrophic factor, maternal peripheral blood, cord blood


Mehmet Aksoy, Ayse Nur Aksoy, Ali Ahıskalıoglu, Ilker Ince, Esra Laloglu, Aysenur Dostbil, Mine Gursac Celık. The Effect of Anaesthetic Techniques on Maternal and Cord Blood Brain-Derived Neurotrophic Factor Levels. Turk J Anaesthesiol Reanim. 2018; 46(2): 139-146

Corresponding Author: Mehmet Aksoy, Türkiye


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