Changes in lung function parameters after total intravenous anaesthesia and balanced anaesthesia with desflurane: a prospective randomized study [Turk J Anaesthesiol Reanim]
Turk J Anaesthesiol Reanim. Ahead of Print: TARD-81594

Changes in lung function parameters after total intravenous anaesthesia and balanced anaesthesia with desflurane: a prospective randomized study

SAURABH SHARMA1, Anju Bhalotra2, Shikha Awal3
1Department of Neuroanesthesia, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
2Department of Anaesthesiology, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India.
3Department of Anaesthesiology, Kalinga Hospital, Bhubaneswar, Orissa, India.

Objective: Following anesthesia there is a decrease in pulmonary function. Unlike volatile anesthetics, propofol decreases upper airway tone and total intravenous anesthesia (TIVA) with propofol may decrease coughing on emergence. Coughing may reduce postoperative atelectasis. Thus TIVA may lead to greater decreases in lung function postoperatively as compared to balanced anaesthesia with desflurane.
Methods: Sixty patients of either sex, aged 18-60 years, ASA status I/II undergoing mastoid surgery were randomly allocated to Group B and Group T. Anaesthesia was maintained with desflurane, nitrous oxide and oxygen in Group B and with TIVA in Group T. Pulmonary function tests (PFT) were done preoperatively and 1, 3 and 24 hours postoperatively.
Results: Demographic data and preoperative PFT were comparable in both groups. One hour after surgery, there was a greater fall in FEV1 and PEFR in Group T (p= 0.044 and 0.042 respectively). Three hours postoperatively, the decrease in MEFR and PEFR was again greater in Group T (p= 0.005 and 0.008 respectively) while the MEFR recovered to preoperative values in Group B. By 24 hours, the FVC, MEFR and PEFR recovered to preoperative values in Group T while FVC remained reduced in Group B (p=0.006).
Conclusion: Both anesthesia techniques cause a postoperative impairment in lung function but while TIVA causes a greater reduction in PFT in the early postoperative period, recovery is also earlier. On the other hand, balanced anaesthesia with desflurane was associated with a greater reduction in PFT at 24 hours.

Keywords: anaesthesia, general, anaesthetic techniques, inhalation, anaesthetic techniques, i.v.; monitoring, spirometry




Corresponding Author: Anju Bhalotra, India


TOOLS
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar