The effect of transversus abdominis plane block for analgesia in patients undergoing liver transplantation: A systematic review and meta-analysis [Turk J Anaesthesiol Reanim]
Turk J Anaesthesiol Reanim. Ahead of Print: TARD-60251

The effect of transversus abdominis plane block for analgesia in patients undergoing liver transplantation: A systematic review and meta-analysis

Ankur Sharma1, Akhil Dhanesh Goel2, Prem Prakash Sharma3, Varuna Vyas4, Sumita Pravesh Agrawal5
1Assistant Professor, Department Of Trauma & Emergency (anaesthesiology), All India Institute Of Medical Sciences (aiims), Jodhpur, Rajasthan - 342005, India
2Assistant Professor, Department Of Community And Family Medicine all India Institute Of Medical Sciences (aiims), Jodhpur, Rajasthan - 342005, India
3Assistant Professor, Department Of Community And Family Medicine All India Institute Of Medical Sciences (aiims), Jodhpur, Rajasthan - 342005, India
4Assistant Professor, Dept. Of Paediatrics all India Institute Of Medical Sciences (aiims), Jodhpur, Rajasthan - 342005, India
5Ex-senior Resident, Dept. Of Pulmonary & Sleep Medicine safdarjung Hospital, New Delhi, India

Background: Ultrasound guided regional anaesthesia using transversus abdominis plane (TAP) block is a newer and safer method that can be used in patients undergoing liver transplant surgeries. This systematic review and meta-analysis was done to quantify the analgesic potential and opioid sparing capability of TAP block in these patients.
Methodology: The studies comparing TAP‑block to conventional analgesic regimens for liver transplant were searched. The studies evaluating the comparative 24-h morphine consumption during postoperative period in patients undergoing liver transplant surgeries were searched and included as the primary outcome in the analysis.
Results: We found 2 randomized control trial and 2 retrospective studies which on metaanalysis showed that TAP block group had significantly lower requirement of morphine (WMD=27.59 mg; 95% CI: 33.47 21.70) at 24 hours for pain mitigation. Also post-operative nausea and vomiting was lower (RR=0.76; 95%CI: 0.47 - 1.22) but not statistically significant.
Conclusions: Ultrasound guided TAP block provides postoperative analgesic efficacy in patients undergoing liver transplant surgeries.

This study was registered in International prospective register of systematic reviews [PROSPERO: CRD42018094595].

Keywords: Transversus abdominis plane (TAP) block, 24 hr morphine, post-operative nausea and vomiting




Corresponding Author: Ankur Sharma, India


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