Comparative evaluation of two doses of Etoricoxib (90mg and 120mg) as preemptive analgesic for postoperative pain relief in mandibular fracture surgery under general anesthesia: A prospective, randomized, double blinded, placebo controlled trial. [Turk J Anaesthesiol Reanim]
Turk J Anaesthesiol Reanim. Ahead of Print: TARD-54614

Comparative evaluation of two doses of Etoricoxib (90mg and 120mg) as preemptive analgesic for postoperative pain relief in mandibular fracture surgery under general anesthesia: A prospective, randomized, double blinded, placebo controlled trial.

DEVALINA GOSWAMI1, Arijit Sardar1, Dalim Kumar Baidya1, Rahul Yadav2, Ongkila Bhutia2, Ajoy Roychoudhury2
1Department Of Anaesthesiology, Pain Medicine And Critical Care, All India Institute Of Medical Sciences, New Delhi, India
2Department Of Oral And Maxillofacial Surgery, All India Institute Of Medical Sciences, New Delhi, India

Objective: This trial investigated efficacy of oral etoricoxib 90mg (E90) and 120mg (E120) in post operative analgesia as compared to placebo (control [C]) in mandibular fracture pain model.
Methods: 60 adult patients with mandibular fracture posted for maxillofacial surgery were randomly allocated to receive etoricoxib 90mg, 120mg and placebo one hour before surgery. Patients were followed up to 24hours. Duration of analgesia, intraoperative and postoperative analgesics requirement, pain score, postoperative patient satisfaction and adverse effects were measured.
Results: Baseline demographic parameters were similar in all groups. Duration of analgesia was longer in both the etoricoxib 120 (6.000.816 hours) and etoricoxib 90 (4.371.008 hours) groups (p <0.05) when compared to placebo group (2.600.821hours). Mean difference of duration of analgesia between etoricoxib120 and etoricoxib 90 was1.62 (95% confidence interval, -0.234-3.484) with a p value >0.05.Post operative pain intensity was significantly lower in both the etoricoxib 120 and 90 mg groups compared to the placebo group. Both the etoricoxib groups required less intraoperative (p value 0.002) and postoperative (p value 0.001) analgesic supplementation compared to control. Patient satisfaction score, incidences of significant adverse effects were similar among all the three groups.
Conclusion: Etoricoxib 90mg is equally efficacious to etoricoxib120mg with similar side effect profile in acute severe pain setting.

Keywords: Etoricoxib, Mandibular fracture, analgesia




Corresponding Author: DEVALINA GOSWAMI, India


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