Randomized control trial comparing plain levobupivacaine and ropivacaine with hyperbaric bupivacaine for cesarean delivery. [Turk J Anaesthesiol Reanim]
Turk J Anaesthesiol Reanim. Ahead of Print: TARD-50465

Randomized control trial comparing plain levobupivacaine and ropivacaine with hyperbaric bupivacaine for cesarean delivery.

Divya Sethi
Employees’ State Insurance Cooperation Postgraduate Institute of Medical Sciences and Research (ESIC–PGIMSR), New Delhi

Objective: The study compared spinal block characteristics of equipotent doses of plain 0.5% levobupivacaine, plain 0.75% ropivacaine and hyperbaric 0.5% bupivacaine for elective cesarean delivery.
Methods: One hundred parturient women undergoing elective CS under spinal anesthesia were enrolled for the study. The parturients were randomly assigned to receive one of the following in a subarachnoid block: hyperbaric 0.5% bupivacaine 10 mg (group B), plain 0.5% levobupivacaine 10 mg (group L), plain 0.5% ropivacaine 15 mg (group R).
Results: Motor block duration [groups B, LB, R: 143.78 (30.43), 139.31 (33.38), 137.32 (27.39) mins, P = 0.80], sensory block duration [groups B, LB, R: 122.87 (34.93)113.03 (39.24), 125.58 (24.93) mins, P = 0.30] and first analgesic request time [groups B, LB, R: 136.87 (28.70), 133.59 (27.30), 144.19 (32.09) mins, P = 0.35] were statistically comparable. The groups were statistically comparable for sensory block onset time [T6 block; groups B, LB, R: 4.62 (2.80), 4.93 (2.63), 5.73 (3.00) mins, P = 0.29] but motor block onset time was statistically prolonged for group R compared group B [Bromage 3 block; group B, LB, R: 5.93 (3.41), 9.00 (4.00), 10.16 (5.66) mins; P = 0.001]. No statistically significant difference was seen in sensory and motor block recovery times, hemodynamic parameters or side-effects.
Conclusion: Spinal block with 10 mg plain levobupivacaine or 15 mg plain ropivacaine is comparable to 10 mg hyperbaric bupivacaine for elective cesarean delivery.

Keywords: levobupivacaine, ropivacaine, bupivacaine, cesarean delivery, spinal block  ,,,




Corresponding Author: Divya Sethi, India


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