Atrial Fibrillation in Patients with Septic Shock: A One-Year Observational Pilot Study [Turk J Anaesthesiol Reanim]
Turk J Anaesthesiol Reanim. Ahead of Print: TARD-44789 | DOI: 10.5152/TJAR.2019.44789  

Atrial Fibrillation in Patients with Septic Shock: A One-Year Observational Pilot Study

Irene Steinberg1, Etrusca Brogi1, Lorenza Pratali2, Danila Trunfio1, Greta Giuliano1, Elena Bignami3, Francesco Forfori1
1Department of Anaesthesia and Intensive Care, University of Pisa, Pisa, Italy
2Institute of Clinical Physiology - National Research Council, Pisa, Pisa, Italy
3Department of Medicine, University of Parma, Parma, Italy

Objective: The negative effect of sepsis on the myocardium affects its electric functionality. This study aims to evaluate the incidence of atrial fibrillation (AF) in patients with septic shock, and the mortality rate of patients with AF versus patients that maintained sinus rhythm (SR).
Methods: This is a one-year observational prospective pilot study. It was conducted at the Department of Anaesthesia and Intensive Care of Pisa University. Patients with septic shock were enrolled in this study. They were divided in two groups based on the occurrence of AF while in the ICU. Data were collected at admission and after 72 hours, and the data consisted of anamnesis, vital parameters, blood results and severity score.
Results: Out of 27 patients, 9 developed AF during the first 72 hours. At admission and at 72 hours, SOFA was statistically higher in the patients with AF (p=0.012 and p=0.002, respectively). In the AF group, the overall mortality was 66.7%, whereas, it was 11.1% (p=0.006) in the patients with SR. Age, rhythm and noradrenaline dosage were univariate predictors of total mortality.
Conclusion: In patients with septic shock, AF has a high incidence, and it correlated with a worse outcome. Patients with higher SOFA score are at a greater risk of developing arrhythmia.

Keywords: Arrhythmia, atrial fibrillation, mortality, sepsis, septic shock, SOFA score




Corresponding Author: Etrusca Brogi, Italy


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