Contribution of pre-hospital blood lactate level for pre-hospital orientation of septic shock - LAPHSUS study [Turk J Anaesthesiol Reanim]
Turk J Anaesthesiol Reanim. Ahead of Print: TARD-42027

Contribution of pre-hospital blood lactate level for pre-hospital orientation of septic shock - LAPHSUS study

Jouffroy Romain1, Jean Pierre Tourtier2, Guillaume Debaty3, Vincent Bounes4, Papa Gueye-ngalgou5, Benoit Vivien1
1Intensive Care Unit, Anesthesiology, SAMU, Necker Enfants Malades Hospital, Assistance Publique - H˘pitaux de Paris, Paris, France
2Fire Brigade of Paris, Paris, France.
3Department of Emergency Medicine, SAMU 38, University Hospital of Grenoble Alps/CNRS/TIMC-IMAG UMR 5525, Grenoble, France
4Department of Emergency Medicine, SAMU 31, University Hospital of Toulouse, Toulouse, France
5SAMU 972 CHU de Martinique Pierre Zobda -Quitman Hospital 97261 Fort-de-France Martinique, France

Background:
In the pre-hospital setting, the severity assessment of septic shock is essential to decide the optimal initial in-hospital level of care. As clinical signs can be faulted, there is a need for an additional element in order to enhance the severity assessment and to decide in-hospital admission in the intensive care unit (ICU) or in the emergency department (ED). Point of care medical device yielding blood lactate levels since the pre-hospital setting may give an easy and valuable element for the severity assessment and the decision-making.
The aim of this study is to provide clinical evidence that the pre-hospital blood lactate level predicts the 30-day mortality of patients with septic shock.
Methods: This trial is a prospective, observational, non-randomized controlled study. A total of 1000 patients requiring mobile intensive care unit intervention for a septic shock in the pre-hospital setting will be included. Pre-hospital blood lactate levels will not be taken into account to decide patients treatments and/or ED or ICU admission. In the pre-hospital setting, each patient will benefit from 2 measurements of blood lactate level: initial measurement at the first contact, and final measurement at the hospital admission with a specific point of care medical device.
Discussion: This study could provide clinical evidence that pre-hospital blood lactate level predicts the 30-day mortality of patients with septic shock. The results from this study could also prove the utility of the pre-hospital blood lactate level value for the triage and early orientation of patients with septic shock.

Keywords: Severe sepsis, septic shock, blood lactate, pre-hospital setting, prediction.




Corresponding Author: Jouffroy Romain, France


TOOLS
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar