Chlorhexidine Allergy: Mild Allergic Reactions Can Precede Anaphylaxis in the Healthcare Setting [Turk J Anaesthesiol Reanim]
Turk J Anaesthesiol Reanim. 2019; 47(4): 342-344 | DOI: 10.5152/TJAR.2019.22058  

Chlorhexidine Allergy: Mild Allergic Reactions Can Precede Anaphylaxis in the Healthcare Setting

Morten Schjørring Opstrup1, Lene Heise Garvey2
1Department of Dermatology, Zealand University Hospital, Roskilde, Denmark;Danish Anaesthesia Allergy Centre, Allergy Clinic, Department of Dermatology and Allergy, Copenhagen University Hospital Gentofte, Gentofte, Denmark
2Danish Anaesthesia Allergy Centre, Allergy Clinic, Department of Dermatology and Allergy, Copenhagen University Hospital Gentofte, Gentofte, Denmark;Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

Chlorhexidine can cause severe immediate-type allergic reactions such as urticaria, anaphylactic shock or, even, cardiac arrest. We report the case of a patient who developed perioperative anaphylactic shock caused by chlorhexidine 1 year after a postoperative urticarial reaction, which was assumed not to be significant at the time. This case highlights the importance of identifying mild allergy symptoms after exposure to chlorhexidine at the pre-anaesthetic assessment to prevent more severe allergic reactions in future.

Keywords: Allergy, anaphylaxis, chlorhexidine, drug allergy, perioperative


Morten Schjørring Opstrup, Lene Heise Garvey. Chlorhexidine Allergy: Mild Allergic Reactions Can Precede Anaphylaxis in the Healthcare Setting. Turk J Anaesthesiol Reanim. 2019; 47(4): 342-344

Corresponding Author: Morten Schjørring Opstrup, Denmark


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