Impact of Preemptive Intravenous Ibuprofen on Perioperative Analgesia in Patients Undergoing Third Molar Extraction: A Randomised Controlled Study [Turk J Anaesthesiol Reanim]
Turk J Anaesthesiol Reanim. Ahead of Print: TARD-09623

Impact of Preemptive Intravenous Ibuprofen on Perioperative Analgesia in Patients Undergoing Third Molar Extraction: A Randomised Controlled Study

İlke Küpeli1, yakup gülnahar2
1Erzincan Binali Yildirim University, Anesthesiology And Reanimation Department, Erzincan
2Erzincan Binali Yildirim University, Oral And Maxillofacial Surgery Department, Erzincan

Objective: The aim of this study was to evaluate the analgesic efficacy of preemptive intravenous (IV) ibuprofen on pain during and after the mandibular third molar surgery.
Methods: Sixty patients were included and allocated as ibuprofen 800 mg IV + dexketoprofen 50 mg (group 1), ibuprofen 800 mg IV alone (group 2), or placebo (group 3). The local anesthetic infiltration was administered to all patients. In all patients, hemodynamic values (mean arterial pressure [MAP] and heart rate [HR]) were recorded preoperatively and infusions started. State-Trait Anxiety Inventory (STAI) scale was used to assess anxiety states. Surgery started 15 minutes after the infusion. Haemodynamic values and pain scores with visual analog scale (VAS) were recorded.Pain scores were recorded postoperatively at rest (VASR) and swallowing (VASS).
Results: There was no significant difference in the preoperative STAI values between the groups (p> 0.05). HR, MAP, and VAS pain scores were significantly higher in group 3 than in groups 1 and 2 (p<0.05). VASR and VASS scores were significantly higher in group 3 than in group 1 in the first 4 h postoperatively (p<0.05). VASS scores were significantly higher in group 3 than in group 2 at 1–4 h postoperatively (p<0.05) but there was no difference in VASR and VASS scores by 48 h after surgery.
Conclusion: Ibuprofen alone or in combination with dexketoprofen provided similar analgesia in the perioperative period when administered preemptively.

Keywords: Pre-Emptive Analgesia, Intravenous Ibuprofen, Pain, Third Molar Surgery, Analgesic Efficacy




Corresponding Author: İlke Küpeli, Türkiye


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